Ana Popović's father first introduced her to the blues, through an extensive record collection and sessions hosted at the family home. Popović founded her first serious band at age nineteen. Within a year, she was playing outside of Yugoslavia and opening shows for American blues icons like Junior Wells. By 1998, her band was doing 100 shows annually and appearinbkg regularly on Yugoslavian television. Her debut CD, Hometown, provided a first glimpse of her talents as a singer and guitarist.
In 1999, Popović relocated to the Netherlands to study jazz guitarr. She quickly became a fixture on the Dutch blues scene and soon ventured into neighbouring Germany. With Comfort to the Soul (2003), Popović delivered another diverse package of blues, Rock, Soul and Jazz.